Powerful Results, Fast Relief
USPlus® Supports Peak Performance for Men’s Urinary HealthMost urinary health products rely on borrowed science. USPlus® offers clinical data your brand can claim—with USP verification to prove its quality.
The Rising Need for Men’s Urinary Health Solutions
Men over 40 years old are increasingly facing the challenges of an aging prostate, revealing a critical demand for an effective, natural solution—met only by USPlus® with its clinically proven results.
30 Million Men Over 40 Are Affected By An Enlarged Prostate
(Benign Prostatic Hyperplasia, BPH)
Percentage of Men with BPH by age
The Overlooked Toll of BPH on Men’s Quality of Life
An enlarged prostate often goes unaddressed, yet its impact on men’s quality of life is profound, turning daily routines into a source of frustration and discomfort.
Early Symptoms Include:
Urinary Frequency
Repeatedly waking up during the night to urinate
Urgency
The need to go to the toilet to urinate more often
Flow
Weak stream and dribbling after urination
USPlus® Delivers Clinically Proven Relief Where Others Don’t
Unlike most products lacking clinical support, USPlus® provides significant relief for men with lower urinary tract symptoms (LUTS) due to BPH, as leading urologists demonstrated in a 2025 study published in The Canadian Journal of Urology™.
65%
Of men improved urinary symptoms
by week 12
(IPSS score)
50%
Stronger stream, reduced straining, urgency & frequency
in as little as 6 weeks
100%
Had improved quality of life with fewer nighttime wakeups & better sleep
by week 12
65%
Reported consumer retention rate by brands using USPlus®
leading to higher loyalty rate
Clinical and Mechanistic Differentiation
USPlus® isn’t just a trusted choice—it’s a scientifically advanced solution that addresses men’s urinary and prostate health at its core, setting your brand apart with a dual-action approach.
Unlike other saw palmetto extracts that lack standardization, USPlus®—rich in bioactive free fatty acids—meets the rigorous 3rd party testing standards of the USP monograph and delivers proven results through two key mechanisms. It inhibits 5α-reductase enzymes 1 and 2, reducing DHT production. When not in balance, these enzymes convert too much testosterone into DHT which leads to an enlarged prostate. By inhibiting the enzyme naturally, it keeps the conversion to DHT in balance which supports healthy urinary flow and addresses LUTS, while also promoting a balanced inflammation response in the prostate for overall health. This dual action ensures USPlus® provides comprehensive relief for men.
USPlus® inhibits 5α-reductase enzymes 1 and 2, similar to the leading
herbal medicine product in Europe.
Inhibition of 5α-Reductase 1
Inhibition of 5α-Reductase 2
Permixon® is a registered trademark of Pierre Fabre Medicament
Cartwright et. al. Lipid profile and 5?-reductase inhibition activity of standardized saw palmetto extracts (USPlus® and Permixon®).
Sourcing and Sustainability with USPlus®
Valensa ensures USPlus® delivers top-quality standardized saw palmetto extract through sustainable practices, supported by our Supply Chain Excellence program (GEMS).
- Vertically integrated supply chain with long-term partnerships with landowners—all within the natural growing region in the Southeastern US
- Provide all stakeholders with full traceability, transparency, and accountability
- Maintain high sustainability standards with the goal of making a positive impact on the environment
- Promote responsible fair trade practices for a sustainable and safe wild-craft harvested crop
See how we ensure excellence in every step—watch world-renowned urologist Dr. J. Curtis Nickel tour our supply chain in this 6-minute video.
Rigorous Standards for Compliance
Our commitment to excellence ensures USPlus® meets the highest standards through rigorous manufacturing, safety, quality, and third-party testing in a certified facility dedicated to natural products, giving your brand confidence in every dose.
USPlus® is the First and Only USP-Verified Saw Palmetto Extract
USPlus® is the only saw palmetto extract with USP verification, the most stringent third-party testing standard, ensuring unmatched quality and monograph compliance. As the leader in standardized saw palmetto LSESr, Valensa provides science, data, and insights to help partners succeed.
What USP verification means:
- Extensive GMP facility audit to 21 CFR Part 117 and USP <2750> standards
- End-to-end product quality control and manufacturing (QCM) process evaluation
- Independent (3rd Party) laboratory testing for identity, purity, and potency
- Verification that the standardized profile is consistently met
Learn how USPlus® achieves its clinical effectiveness—watch Deep Extract®: Valensa’s Patented Process for a Clinically Effective Saw Palmetto Extract.
Quality You Can Trust
USPlus® delivers quality you can rely on, ensuring consistency and transparency at every step.
- From Florida-grown harvest
(Only source in the World) - Made in the USA with 100% solvent-free supercritical CO2 extraction
- Only standardized saw palmetto extract with USP verification
- Undergoes rigorous third-party testing by USP
- Guaranteed to deliver clinical dose and bioactive free fatty acid profile
- Manufactured in an FDA-registered facility adhering to strict cGMP standards
Curious about your current saw palmetto oil? Request a free analysis to see how USPlus® compares.
Formulated for Flexibility
USPlus® empowers your brand with versatile formulation options to meet diverse market needs. Available in soft gels, capsules, gummies, and powder for beverages, USPlus® adapts seamlessly to your product vision while delivering proven men’s urinary and prostate health benefits. Explore the possibilities and request detailed product specifications today.
Leading Brands Like Trunature Trust USPlus®
Trunature Prostate Plus Health Complex relies on USPlus® , the standardized saw palmetto extract recommended by experts, to deliver exceptional Men’s urinary health support, leveraging its clinically proven benefits in a trusted formula to meet consumer needs.
Consumer Confidence: USPlus® Takes the Spotlight
Consumers are buzzing about Trunature Prostate Plus Health Complex, powered by USPlus®, and its availability at Costco.
